Industrial
Substantial, superior value via a one-stop package of customised solutions, quality service and technical support, with single-point contact....
Industrial
Substantial, superior value via a one-stop package of customised solutions, quality service and technical support, with single-point contact....
Industrial
Substantial, superior value via a one-stop package of customised solutions, quality service and technical support, with single-point contact....
Pharma

Case Study

The Challenge:
A multinational pharma company in Asia undertaking a rapid expansion needed to meet stringent USP 28 guidelines for high purity water for injectibles. The existing chemically sanitisable RO-EDI system did not meet the demands of regulated markets and besides, required considerable maintenance. The customer sought a dependable system vendor for a new unit that would meet their need for high purity water, and entrusted Ion Exchange with the responsibility.

The Solution:
We recommended a Hot Water Sanitisable INDION High Purity Water (HPW) plant consisting of:

  • Ultra filtration
  • Softening
  • Heat Sanitisable Reverse Osmosis (RO)
  • Heat Sanitisable Electro Deionisation (EDI)
  • Heat Sanitisable Ultra Filtration system
Since the customer was using surface water, UF was incorporated in pretreatment to handle suspended solids and colloids. A heat sanitisable UF system was also offered as a polishing unit downstream of the EDI to remove endotoxins/bacteria from the product water. The factory acceptance test (FAT), witnessed by the customer, was ensured prior to dispatch of the RO-EDI plant.

Result:
Conductivity  < 1.25
TOC              < 500 ppb
Bacteria        < 10 CFU / 100 ml
Endotoxins    < 0.25 EU/ml

  • Chemical-free sanitisation and virtually maintenance-free system
  • Less manpower required due to high degree of automation
  • Extensive validation documentation made periodic USFDA audits effortless for the customer